As many of you know, the song comes from Dylan’s 1965 album Highway 61 Revisited—& of course, the “Highway 61” of the title is the “Blues Highway”—U.S. 61 that runs from New Orleans, Louisiana up thru the Mississippi Delta region, eventually coming to an end in Wyoming, Minnesota. Dylan himself said of the Highway 61 Revisited album:
"I'm not gonna be able to make a record better than that one... Highway 61 is just too good. There's a lot of stuff on there that I would listen to."
(from Wikipedia)
I sure had fun with this—hope you enjoy it, too!